"I believe MDA is a great alternative to oral gavage in many fields. In the field of vaccines, it is a technique that improves welfare and better mimics future use in other animals or humans, making it excellent for improved translatability and optimization of animal use."

Dr. Beatriz Miguelana
Chamorro

ICTYODEV

"Using the MDA approach, we can completely replace oralgavage in the mouse oral glucose tolerance test (oGTT). The oGTT is a commonlyused metabolic test in human medicine and preclinical animal research, whichassesses how well blood glucose control systems are working in the body and isused to help diagnose diabetes. For our purposes we have adapted the MDAapproach using flavoured glucose solution instead of sweetened condensed milkand found that the addition of the flavouring was essential to promote habituationto voluntary glucose drinking. The MDA is much less stressful for both theanimals and the investigators. As voluntarily drinking via MDA incorporatesglucose sensing by the mouth it is much more similar to the human clinicalassay making the approach more translationally relevant. It is our hope thatour new approach will become the standard oGTT method for the field andcompletely replace oral gavage."

Prof. Dr. Kate Ellacott

University of Exeter Medical School

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